Distinct psychophysiological biomarkers and risk stratification models for irritable bowel syndrome with constipation (IBS-C) and diarrhea (IBS-D) (opens in new tab)

Irritable bowel syndrome (IBS) is a prevalent disorder of gut-brain interaction (DGBI) with a complex, multifactorial pathogenesis. Emerging evidence underscores the significant role of psychosocial factors; however, comprehensive models integrating multidimensional psychophysiological biomarkers to predict IBS subtypes often lack validation in this highly heterogeneous population. To evaluate the value of a psychophysiological multimodal approach in identifying predictive signatures for irri...