Persistent homology-based multiscale Hi-C analysis uncovers TADs-mediated gene regulation (opens in new tab)

Topologically associating domains (TADs), computationally defined 3D chromatin structures, play pivotal roles in gene expression regulation and genome organization. However, their structural basis and functional implications remain contentious. The interplay between TADs and other multiscale 3D chromatin structures has not been comprehensively computationally characterized. The extent and regulatory scope of TAD-mediated gene expression continue to be debated. Multiscale analyses spanning hie...