Benchmarking the prediction of responding cells to perturbations affecting both gene expression and cellular abundance using scRNA sequencing (opens in new tab)

Defining how cells respond to perturbations is crucial for understanding their biology. While previous works were designed to classify responding cells, methods for quantifying the response of each cell are not well developed. In addition, perturbations affecting only gene expression were considered for modeling. However, perturbation not only alters the gene expression of cells but also alters cellular abundance. But to date, no validation data is available to assess such perturbations. To a...