One-pot click synthesis of hybrid triazole–pyridine-functionalized polyphenol derivatives under ultrasound irradiation and their antimicrobial assays (opens in new tab)

In the present work, we describe an efficient, straightforward, and environmentally friendly method for synthesizing hybrid triazole-pyridine-functionalized polyphenol derivatives via a one-pot, three-component click reaction under ultrasound irradiation. The reactions are high-yielding (65–90%), require shorter reaction times, use lower solvent volumes, show notable acceleration, and involve lower energy consumption. Taking into account the 12 principles of green chemistry and the above cons...