Hydrogen sulfide inhalation induces changes in body physiology and lung gene expression in mice (opens in new tab)

Hydrogen sulfide (H2S) inhalation injures the respiratory, immune, and nervous systems, altering homeostasis and health, but the molecular mechanisms have been still unclear. In this study, we tested the effects of different concentrations of H2S on immune index and enzyme activity of mouse tissues and measured differentially expressed genes (DEGs) in mouse lung tissues by transcriptome sequencing. The results showed that H2S significantly increased tumor necrosis factor-alpha (TNF-α) (p < 0....