Curcumin modulates oxidative stress, cortical activity and corticosterone in mice exposed to chronic social stress in the spontaneous aggressiveness model (opens in new tab)

Stress constitutes a fundamental physiological mechanism essential for survival and environmental adaptation. Chronic social stress is a major risk factor for emotional and behavioral disturbances, including aggressiveness. Curcumin, a bioactive polyphenol derived from Curcuma longa, exhibits antioxidants, anti-inflammatory, and antidepressant properties, making it a promising neuroprotective agent. Previous studies using the Spontaneous Aggressiveness Model (MSA) demonstrated increased produ...