Comparative dementia and Parkinson’s disease risk associated with melatonin, benzodiazepine, or zolpidem use in patients with sleep disorders: a retrospective c... (opens in new tab)

Melatonin is widely used for sleep disorders and has been hypothesized to exert neuroprotective effects. However, real-world evidence regarding its long-term association with neurodegenerative outcomes remains limited and may be confounded by prodromal sleep disturbances related to early neurodegenerative disease. We conducted a retrospective target trial emulation using the TriNetX Global Collaborative Network between 2015 and 2024. Adults aged ≥ 50 years with sleep disorders identified usin...