Linking microarchitectural deterioration to altered tissue-level mechanical environments in ovariectomized mouse femora (opens in new tab)

Estrogen deficiency is a primary driver of osteoporotic bone fragility. While its morphometric characteristics are well-documented, the different tissue-level mechanical environments across femoral regions remain poorly characterized. This study employed an integrated experimental-computational approach, utilizing ex vivo femoral three-point bending data and high-resolution micro-computed tomography (microCT) images from a mouse model. We quantified morphometric parameters within distal metap...