Liquid crystal-like self-organization of glioblastoma is associated with consistent migration for high cell densities (opens in new tab)

Glioblastoma is the most lethal and frequent type of primary brain tumors, characterized by a high proliferative and infiltrative capacity. Here, we used live cell imaging to analyze the effect of cell density variations on the migratory capacity of established and primary glioblastoma cell lines. We found that proliferation events promoted local velocity of glioblastoma cells, up to three cell-length away from the proliferation event. Furthermore, two phenotypes were found when subjecting gl...