Photobiocatalytic stereocontrol of two prochiral radicals (opens in new tab)

Stereocontrol over radical intermediates is highly sought after in asymmetric organic synthesis, yet current approaches remain limited and difficult to generalize. A photobiocatalytic strategy employing thiamine diphosphate (ThDP)‑dependent enzymes now achieves simultaneous and precise control over two prochiral radical intermediates, enabling new‑to‑nature C(sp3)–C(sp3) bond formation with high enantio‑ and diastereoselectivity.