Stereoselective photometallobiocatalytic cross-coupling of organoboron reagents and diazo compounds via an outer-sphere mechanism (opens in new tab)

Designing and developing synthetically useful biocatalytic reactions that operate through unconventional mechanisms represent a central challenge in modern biocatalysis research. By coupling photoredox catalysis and metalloenzyme catalysis, here we harness cooperative photometallobiocatalysis to merge enzymatically generated, open-shell iron carbenoids with reactive radical intermediates formed via excited-state chemistry. This strategy expands the scope of intermolecular radical C–C coupling...