Wavelength-dependent sleep state manipulation using light pulses in Pogona vitticeps (opens in new tab)

Slow-wave (SW) and rapid eye movement (REM) sleep states are defining features of mammalian sleep. Controlling them is key to unraveling their function and developing therapeutic strategies for sleep disorders. We investigated sleep state manipulation using light in Pogona vitticeps, a lizard exhibiting highly structured, periodic transitions between sleep states. We demonstrate state entrainment using light pulses, overriding the natural sleep state rhythm, and revealing a mechanism for non-...