Non-classical NMDAR subunit GluN3A in a specialized hippocampal region regulates stress-coping strategies in male mice (opens in new tab)

The hippocampus exhibits marked structural, functional, and molecular heterogeneity. GluN3A, a non-classical N-methyl-D-aspartate receptor subunit enriched in hippocampal CA1, has a poorly understood role in stress-related behavior. Here, using chronic social defeat stress (CSDS), GluN3A knockout mice, and behavioral, molecular, genetic, pharmacological, and circuit analyses, we investigated the role of hippocampal GluN3A in stress coping. CSDS selectively reduced GluN3A expression in interme...