Single-cell long-read profiling of olfactory sensory neuron differentiation and diversity (opens in new tab)

Olfactory sensory neurons comprise a population of highly heterogeneous subtypes. One important mechanism contributing to neuronal diversity is post-transcriptional regulation, in which isoform heterogeneity is an important component. Comprehensive profiling of transcript isoforms in olfactory sensory neurons is therefore essential for understanding the molecular mechanisms underlying their diversity. By integrating single-cell long-read sequencing with conventional 3’ RNA sequencing, we demo...