Identifying omic biomarkers for chronic inflammatory diseases associated with periodontitis using percolation on multi-disease gene co-expression networks (opens in new tab)

Chronic inflammatory diseases, such as ulcerative colitis (UC), Crohn’s disease (CD), Alzheimer’s disease (AD) and Parkinson’s disease (PD) are clinically related to periodontitis. However, the computation of omic biomarkers regarding these diseases has not leveraged this association. We developed PMGCN, a computational framework that employs optimal percolations on multi-disease gene co-expression networks derived from bulk transcriptomic gene expression profiles to identify a parsimonious s...