Taming distonic radical cations for precise γ-C–H functionalization of alkylamines (opens in new tab)

Alkylamines are crucial structural motifs found in 43% of active pharmaceutical ingredients, where they interact with biological targets. As a consequence, the C–H functionalization of alkylamines is a powerful strategy for accelerating drug development. Remote C–H functionalization enables selective modification of the periphery of the active nitrogen site and can improve bioactivity and pharmacokinetics. Unlike that of primary and secondary alkylamines, the remote functionalization of terti...