Angle-strained cycloalkyne-mediated carbonyl 1,2-transposition (opens in new tab)

Carbonyl 1,2-transposition represents a powerful yet challenging transformation in molecular editing, enabling the precise repositioning of ketone functionalities within carbocyclic frameworks. While this approach holds significant promise for streamlining synthetic routes and tailoring molecular properties, efficient methods for relocating carbonyls in five-membered ring substrates remain an unmet challenge. Here we report a strain-release-driven strategy for the one-pot translocation of car...