Catalytic enantioselective tandem B–H insertion and [3,3]-sigmatropic rearrangement (opens in new tab)

[3,3]-Sigmatropic rearrangements are powerful transformations in synthetic chemistry, enabling atom-economical construction of complex architectures through stereospecific molecular skeleton reorganization. Despite their widespread utility, achieving asymmetric catalysis of [3,3]-sigmatropic rearrangements remains a substantial challenge due to the difficulty in controlling the stereochemistry and the limited availability of catalytic systems compatible with diverse substrates. Here we report...