Electrophotocatalytic decarboxylative vicinal dichlorination of aliphatic carboxylic acids (opens in new tab)

Decarboxylative functionalization of aliphatic carboxylic acids is a powerful strategy in organic synthesis, yet most methods focus on decarboxylative monofunctionalization. Merging decarboxylation with selective activation of an adjacent C–H bond to deliver vicinal difunctionalization has remained elusive. Here we report an electrophotocatalytic decarboxylative vicinal dichlorination of aliphatic carboxylic acids using 1,2-dichloroethane as both the solvent and the chlorine source. Mechanist...