Neurobiomarker-guided neuromodulation for youth with major depressive episodes: a double-blind randomized trial (opens in new tab)

Strong heterogeneity limits precision medicine in youth with mood disorders during major depressive episodes (MDE). Here we propose and evaluate a neurobiomarker-guided repetitive transcranial magnetic stimulation (rTMS) strategy in a double-blind randomized controlled trial. Using multicenter resting-state functional magnetic resonance imaging data (N = 2,328), we validated functional imbalance along the sensorimotor–association axis as a robust neurobiomarker distinguishing two neurosubtype...