Dysregulation of autophagosome–mitochondria contacts contributes to autophagy dysfunction and neurodegeneration in tauopathy (opens in new tab)

Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceMitochondria interact with other organelles by forming membrane contacts that serve as critical signaling hubs. In this study, we revealed the dysregulation of an autophagosome–mitochondria contact in tauopathy neurons. Such defects are caused ...