A GTP synthase ribozyme with increased GTP turnover (opens in new tab)

Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceAn early stage of life must have used catalytic RNAs (ribozymes) to self-replicate in a prebiotic environment. Self-replication would have required RNA polymerization from chemically activated nucleotides, which exist in today’s biology as ...