A protective role for APP in nuclear waste clearance via lysosomal exocytosis (opens in new tab)

Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceResearch on Alzheimer’s disease (AD) has largely focused on amyloid-β, a fragment of the amyloid precursor protein (APP). However, the physiological functions of APP remain poorly understood. Here, we show that APP protects cells by clearing ...