LEF1 binding specificity shapes cellular and tumor phenotypes (opens in new tab)

Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceWnt/β-catenin signaling is crucial for development and cancer, yet how it drives different gene programs across tissues is unclear. Using patient-derived liver tumor organoids, we show that β-catenin’s transcriptional output depends on its ...