Disruption to TFEB signaling and autophagy in newly formed oligodendrocytes leads to aberrant generation of CNS myelin (opens in new tab)

Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceThe cellular and molecular mechanisms governing myelin integrity during axon ensheathment remain poorly understood. Using volume electron microscopy and a knock-in mouse line labeling newly formed oligodendrocytes and their myelin sheaths, we ...