Resveratrol isomers with opposing activities target endonuclease G to modulate neurodegeneration and mitochondrial elimination (opens in new tab)

Proceedings of the National Academy of Sciences, Volume 123, Issue 25, June 2026. SignificanceMitochondrial endonuclease G (EndoG) affects multiple important cellular processes, including paternal mitochondrial elimination (PME) and neurodegeneration. We identified resveratrol (RSV), a natural compound, as a PME inhibitor. RSV exists ...