Targeting the cGAS–STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model (opens in new tab)

Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceHuntington disease (HD) is a hereditary neurodegenerative disorder with prominent inflammation and no disease-modifying therapies. We identify the DNA-sensing cGAS–STING pathway as a key driver of HD-related inflammation and cellular stress. ...