Hp1bp3 loss links chromatin reorganization to metabolic vulnerability in glioma (opens in new tab)

Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceHigh-grade gliomas (HGGs) are aggressive brain tumors that rely on metabolic adaptations to sustain proliferation and survival. Using an immunocompetent mouse model of HGG, we show that dietary methionine restriction reduces tumor ...