Alpha-synuclein fibrils induce budding of mitochondrial-derived vesicles (opens in new tab)

Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. α-synuclein (α-syn) aggregation is a hallmark of synucleinopathies, a class of neurodegenerative disorders such as Parkinson’s disease (PD). Several lines of evidence indicate the involvement of mitochondria in the disease pathology. Despite extensive ...