Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 (opens in new tab)

Proceedings of the National Academy of Sciences, Volume 123, Issue 24, June 2026. SignificanceTip links gate mechanotransduction channels in cochlear hair cells and have been proposed to be the gating springs for the transduction channel. The ultrastructure of the tip link remains not well defined. Here we have used cryo-electron ...