An available drug block the nuclear export of R-loops (opens in new tab)

A new Nature Aging study suggests that senescent cells may drive inflammaging through a previously underappreciated mechanism: the nuclear export of R-loops. The authors show that R-loops, normally nuclear DNA–RNA hybrid structures, can be exported into the cytoplasm through a DDX1–XPO1 complex in senescent cells. Once in the cytoplasm, these R-loops activate the cGAS–STING pathway, amplifying the SASP and systemic inflammation. In old mice, blocking XPO1 with selinexor reduced cytoplasmic R-...