Better-Tuned Mitochondria, Same Tired Legs: High-Dose Ubiquinol Tightens Energy Coupling but Delivers No Performance Edge (opens in new tab)

Six weeks of high-dose ubiquinol (the reduced, more bioavailable form of CoQ10) made the energy-producing machinery inside human muscle measurably more efficient by cutting wasteful “leak” respiration, but this internal upgrade produced no improvement in exercise capacity, oxygen uptake, or economy. Coenzyme Q10 has been marketed as an energy and endurance booster for decades, yet the evidence has been stubbornly underwhelming. A new placebo-controlled trial from Loughborough University helps...