Can't Exercise? Sulforaphane from Broccoli Sprouts Reverses Frailty in Aging Mice (opens in new tab)

Aging skeletal muscle loses the ROS-generating enzyme NOX4, which cripples the NFE2L2 (Nrf2) antioxidant defense system that exercise normally switches on; deleting NOX4 in mice triggers full-blown sarcopenia, frailty, insulin resistance, and even liver disease — all reversible by restoring NOX4 or by giving the broccoli compound sulforaphane. Everyone knows exercise keeps you younger. This paper claims to pin down one of the molecular reasons why — and to show what happens when that mechanis...