Jumping the clock: Engineering ageing in biomedicine (paper 16 June 26) (opens in new tab)

chatGPT(5.5 paid): The paper is a short Forum article proposing “age engineering” or “ageneering”: deliberately manipulating the age-like state of cells, extracellular matrix, and engineered tissues in vitro. The motivation is that many tissue-engineered models, organoids, spheroids, and organs-on-chips use cells without considering whether they resemble young or old tissue, even though ageing changes genomic stability, epigenetics, metabolism, ECM composition, mechanics, and intercellular si...