Multiorgan transcriptomics and circulating extracellularvesicle profiling reveal age‑dependent systemic vulnerabilityto isoflurane anesthesia and surgery (opens in new tab)

SpringerLink Multiorgan transcriptomics and circulating extracellular vesicle profiling... Elderly patients exhibit heightened susceptibility to postoperative complications following general anesthesia and surgery, yet the molecular mechanisms driving this age-dependent vulnerability remain poorly defined. We performed RNA sequencing on... chatGPT(5.5paid) This paper studies how age changes the biological response to isoflurane anesthesia plus laparotomy surgery in mice. The authors used youn...