Pushing the Limits of Cardiovascular Longevity: Intensive Blood Pressure Targets Safely Extend Lifespan in the Very Old (opens in new tab)

Aggressive blood pressure reduction below 130/80 mmHg in older adults—including those over 80—significantly lowers the incidence of major cardiovascular events and all-cause mortality without elevating the risk of serious clinical adverse events. This real-world study challenges the long-standing clinical dogma that blood pressure targets should be loosened as patients age. For decades, clinicians and guideline committees have engaged in a conservative tug-of-war regarding hypertension target...