Quenching the Vascular Fire (NLRP3): How Phytochemicals Combat the Residual Inflammatory Risk of Heart Disease (opens in new tab)

This comprehensive review evaluates the immunomodulatory potential of natural complex extracts and single bioactive compounds that target the NLRP3 inflammasome axis to halt sterile vascular inflammation. It provides a roadmap for shifting cardiovascular therapeutics from basic lipid reduction to advanced immunometabolic reprogramming. For decades, cardiologists treated atherosclerotic cardiovascular disease (ASCVD) primarily as a passive plumbing issue driven by excess cholesterol accumulati...