Sweating Away the Epigenetic Clock: How Exercise Preserves the Core Engine of Human Vitality (opens in new tab)

This comprehensive review outlines how regular exercise training directly mitigates age-related declines in the World Health Organization’s concept of “vitality capacity” by rejuvenating mitochondrial function, metabolic flexibility, neuromuscular strength, immune responses, and the epigenetic methylation clock. The traditional approach to measuring aging often relies on isolated functional metrics, such as gait speed or grip strength. However, a growing consensus within the longevity communi...