A long-read RNA sequencing and polysome profiling framework reveals transposable element-driven transcript diversity (opens in new tab)

More than half of the human genome is made up of transposable elements, often called “jumping genes.” These sequences are usually inactive, but in cancer they can become active again and interfere with normal gene regulation. Understanding how they affect RNA processing is important for uncovering how cancers like glioblastoma develop and evolve. ...