Deep learning–enabled discovery of antibiotics effective against Neisseria gonorrhoeae (opens in new tab)

The development, validation, and deployment of a deep learning model to identify antibiotic hit compounds for N. gonorrhoeae is described. Editor’s summary Neisseria gonorrhoeae, a well-known cause of sexually transmitted disease, has grown increasingly treatment resistant, and identifying effective ways to tackle this pathogen is an utmost priority. Here, Anahtar et al. developed and validated a deep learning model before using it to explore chemical space for molecules predicted to inhibit ...