As a developer working primarily with Next.js and NestJS, I recently reviewed a pull request to a Django project authored by another developer — and realized just how much the Python ecosystem has evolved since I last used it professionally. In this post, I’ll document the process of setting up a modern Python + Django environment from a Node.js developer’s perspective.

The Python Environment setup

Since I last used Python professionally, the ecosystem has changed. virtualenv is still around and doing fine, but venv has been part of the standard library since Python 3.3. And now there’s uv — a modern, fast tool trying to consolidates the functionality of multiple utilities.

Let’s compare them across virtual environments, project management, and packaging. Spoiler: I’m…

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