I’ve had countless genetic tests over the years. I know my medication sensitivities, disease risks, and even my skin cancer predisposition. But when the Creator Marketing Manager at Sequencing.com — a platform for whole-genome analysis — reached out, I was curious to dive in again.

As always, this is not a sponsored post. I received a free test, but I don’t accept payment for reviews. What follows is my honest, hands-on experience.

Who Are They?

Sequencing.com provides comprehensive insights into health, wellness, medication reactions, and genealogy by analyzing your entire genome. Their mission is simple but ambitious: to empower people to take control of their health and make informed decisions based on their DNA.

Sampling is straightforward: a quick buccal swab that takes only a few minutes. The waiting time for results is about a month, which is fairly standard for full-genome sequencing.

What Kind of Results Do You Get?

Once the data is processed, you get access to a wide range of reports organized into categories like:

• Nutritional & Metabolic Health
• Medication & Drug Response
• Brain Health
• AI Cardiovascular Health
• Cancer Risk
• Healthcare Pro
• Wellness and Longevity

Each report lists how many conditions, genes, and variants were screened. They’re also categorized by confidence level (high, medium, or low), with clear counts for risk factors, carrier states, and medication responses.

My Key Findings

1. Carrier of Two Rare Genetic Conditions The first was 3-Methylglutaconic Aciduria Type I (MGCA1)—a rare metabolic disorder caused by mutations in the AUH gene. It affects how the body breaks down the amino acid leucine. Since the condition is autosomal recessive, it only manifests if both parents carry faulty copies. I also carry a variant for Glycogen Storage Disease XV. We already have two children and don’t plan to have more, but if we were before family planning, I’d definitely want to know this and have my partner tested as well.
2. Medication Sensitivities Confirmed The report reaffirmed previous results: I’m sensitive to statins and certain antidepressants. It’s always reassuring to see cross-validation between tests.
3. Cancer Risks With medium confidence, the software suggested elevated risks for lip and oral cavity carcinoma and lung cancer. I already see my dentist twice a year and get a low-dose CT every two years: so my preventive routines are in place.
4. Healthcare Pro Report Highlights
   • Hypercholesterolemia: Genetic, so not easily improved through diet, but statin sensitivity complicates treatment.
   • Factor V Leiden mutation: I’ll visit a thrombosis specialist to learn preventive steps, especially before long flights.
   • Cardiovascular Risk: 57% compared to a 40% population average. I don’t smoke, exercise regularly, eat well, and just had a cardiac CT scan.
   • Knee Osteoarthritis: High genetic risk. I still run and play football, but I counterbalance that with therapy and recovery tools.
   • Atrial Fibrillation: My smartwatch and recent cardiac exam help me monitor it closely.
   • Colon Cancer: Regular colonoscopies every five years since age 35.
   • Melanoma: I get screened yearly, and practically live like a vampire.
   • Brain Aneurysm: Recent MRI was clear.
   • Noise-Induced Hearing Loss: No issues detected.
   • Asthma & Lactose Intolerance: The latter appeared in adulthood, which I can confirm first-hand.

What’s New: AI Integration and Evolving Reports

Sequencing.com includes generative AI as part of its platform. You can chat with an AI assistant trained to interpret your genetic data, an interesting step toward making genomics more accessible.

They also update reports as new research emerges, and you can buy additional reports in their marketplace. For example, I tried the Einstein Report to see if we might be distantly related. Sadly, no luck there.

However, not all results are clear-cut. Many findings come with low confidence levels, which is why I strongly recommend reviewing them with a genetic counselor rather than making any decisions on your own.

How Much Does It Cost?

Depending on the package, prices range from $399 to $999, which is competitive for full-genome sequencing services.

My Verdict

The sampling and setup processes were effortless, and accessing results was simple. The dashboard is modern and intuitive, but the overlap between reports (e.g., cancer risks appearing in both Cancer and Healthcare Pro sections) can be confusing.

Overall, Sequencing.com delivers on its promise: empowering individuals with deep genomic insight. But interpreting the findings requires care, context, and professional guidance, because having your entire genome in front of you is as humbling as it is empowering.

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