College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 10
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The first Saturday of November is here, bringing a slate of significant showdowns across the college football landscape as conference title races heat up. College Football Playoff implications are also starting to get real with the first CFP rankings of the season set to be released Tuesday, giving teams a clearer sense of where they stand entering the home stretch.

No. 1 Ohio State is well-positioned to claim the top spot in the initial rankings if it can hold off Penn State at home in a noon Eastern kickoff. The early window also features a top-20 SEC clash as No. 9 [Vanderbilt](h…

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