When you open Microsoft Excel to review quarterly results or check Waze to optimize your route to the office, you’re tapping into technologies born not in corporate boardrooms, but in university labs. Thinking of innovation, our minds often jump to the titans of tech: Jobs, Musk, Altman, Gates, Bezos. But behind everyday tech innovations and healthcare breakthroughs are academic researchers whose work catalyzed billion-dollar industries.

The unsung heroes of the lab and lecture hall have laid the groundwork for some of the most transformative technologies of our time. A few make celebrity status as Nobel prize winners, but the glory of most academics is poorly understood for its formative early impact on products now essential to our lives—civic, commercial, and medical.

As we gather for the World Changing Ideas Summit on November 19 in Washington, DC, cohosted by Fast Company and Johns Hopkins University, we shine a spotlight on those whose curiosity-driven research has sparked breakthroughs that quietly shaped the world around us.

ACADEMICS AND THE INNOVATION ECONOMY

Here are four ways academic researchers have quietly shaped America’s innovation economy and impacted daily life.

1. GPS: The backbone of modern logistics

You have probably tried to optimize your driving time and cherished every minute saved from your commute. Google Maps has over 2.2 billion monthly active users, and 71% of U.S. smartphone users rely on it weekly. At the root of this technology is the global positioning system (GPS), whose origins trace back to 1957. When Sputnik launched, two young physicists at the Johns Hopkins Applied Physics Laboratory (APL)—William Guier and George Weiffenbach—driven by the national urgency of the Cold War and scientific curiosity, used the Doppler shift of Sputnik’s radio signals to determine its orbit. They and others at APL soon realized the inverse was also true. Their breakthrough inspired the world’s first global satellite navigation system, sponsored by DARPA and the U.S. Navy. This innovation, aimed at solving national security challenges for the U.S. government, became the foundation for modern GPS, revolutionizing navigation and telecommunications for military, government, and civilian applications—from global defense operations to everyday delivery routes.

2. Spreadsheets: A new language for business

According to a survey, 84% of office workers use Microsoft Excel daily. Thank you, Bill Gates, right? Not so fast. The spreadsheet was not actually born in the Seattle tech scene; that credit goes to Dan Bricklin and Bob Frankston, students at Harvard and MIT. VisiCalc, the first spreadsheet software, was thought of as a “magic blackboard,” revolutionizing business modeling. The two weren’t aiming for market disruption, but simply trying to make homework easier. Bricklin was frustrated by tediously recalculating financial models by hand; Frankston, an experienced coder, helped bring it to life. VisiCalc launched in 1979 from a shared belief that computers should empower people. Their work was nurtured in university settings, supported by federal research grants and computing infrastructure. What began as an academic collaboration became the backbone of how we financially model today—from managing family budgets to forecasting industry trends. One could argue that this technology catalyzed our data-driven economy.

3. Self-driving cars: Autonomy realized

Science fiction has arrived! That’s what I was thinking as I stepped into my first self-driven Jaguar in San Francisco, courtesy of Waymo. Waymo alone operates over 1,500 robotaxis across major U.S. cities, with plans to expand to 3,500 vehicles by 2026. The roots of this revolution trace back to Sebastian Thrun, a German-born scientist, whose childhood love of robotics and desire to reduce traffic fatalities led him to Stanford. There, he directed the Artificial Intelligence Lab and spearheaded a team that won the DARPA Grand Challenge, a competition funded by the U.S. Department of Defense. That success caught Google’s attention and ultimately led to the creation of Waymo and a multi-billion-dollar industry.

4. Cancer detection: Learning what to look for

Cologuard has been used over 16 million times. detecting more than 623,000 cancers and precancers, with 80% caught in the early stages. This technology started with the journey of Bert Vogelstein, a Johns Hopkins oncology researcher fixated on a simple scientific question: Why do some cells become cancerous? At Johns Hopkins, supported by sustained federal funding from agencies like the National Institutes of Health, Vogelstein, Ken Kinzler, and colleagues spent decades unraveling the genetic mutations behind tumor development. Their work led to the discovery of p53, a key tumor suppressor gene, and laid the foundation for our modern understanding of cancer as a genetic disease. Researchers’ insights into cancer cell origins enabled industry to develop methods for detecting disease. Today, we rely on genetic tests for early cancer detection, prenatal screenings, and personalized medicine.

IT TAKES THREE PARTS

So how do ideas from a university lab end up in your pocket or your car? It’s a well-tested recipe. American innovation thrives on a three-part formula: federal investment, university research capabilities, and private sector development.

Federal funding fuels foundational science, long before there’s a market. Universities cultivate talent and ideas, allowing researchers to follow where the science leads rather than what a corporate budget dictates. Once science shows promise, the private sector tailors the science toward specific applications and scales those ideas into products and companies.

Since 1980, federally funded academic research has resulted in over 17,000 startups and $1.9 trillion in economic output. But as global competition intensifies, the U.S. must double down on its research ecosystem.

This tripartite innovation ecosystem is not just a source of economic strength. It’s a reflection of our American values: open inquiry, public good, and the belief that big ideas can come from anywhere. This three-pronged approach unleashed a century of American technological leadership. At a time when federal research funding is being severely cut, we are wise to remember its central role in our economy—and its promise for American leadership throughout this century.

Christy Wyskiel is senior advisor to the president for innovation and entrepreneurship, and executive director of Johns Hopkins Technology Ventures.