Data availability
The metagenomic sequencing data generated in this study were deposited in the NCBI SRA database (accession code PRJNA1189811). The transcriptome sequencing data generated in this study were deposited in the NCBI SRA database (accession code PRJNA1189824). All data supporting the article are included in the main article, Supplementary Information, Supplementary Data 1, Supplementary Data 2, and the Source Data file. Source data are provided with this paper. The Source data file has been deposited in the Figshare repository [https://doi.org/10.6084/m9.figshare.30675941].
References
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Data availability
The metagenomic sequencing data generated in this study were deposited in the NCBI SRA database (accession code PRJNA1189811). The transcriptome sequencing data generated in this study were deposited in the NCBI SRA database (accession code PRJNA1189824). All data supporting the article are included in the main article, Supplementary Information, Supplementary Data 1, Supplementary Data 2, and the Source Data file. Source data are provided with this paper. The Source data file has been deposited in the Figshare repository [https://doi.org/10.6084/m9.figshare.30675941].
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Acknowledgements
We thank Gang Shu for gifting the Sucnr1-KO mice, Lifen Gao for gifting the RAW264.7 cell line, Wencheng Zhang and Jingyuan Li for assistance with respiratory metabolic assays, Wenchu Qian, Tiantian Zeng, and Yizhuo Chen for organizing reference materials. This work was supported by the National Natural Science Foundation of China (No. 32330101, 82202007, 82170887, H.L.), the National Key Research and Development Program of China (No. 2021YFD1300405, H.L.), the Natural Science Foundation of Shandong Province, China (No. ZR2023MC085, H.L., H.F.L), and the Third People’s Hospital of Chengdu Clinical Research Program (CSY-YN-01-2023-011, 076, 077, H.F.L). The graphical abstract was created with Figdraw.com (Copyright Certificate ID: TTSUP444f8).
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Author notes
These authors contributed equally: Shuang Liu, Haifang Li.
Authors and Affiliations
College of Animal Science and Technology, Shandong Agricultural University, Tai’an, People’s Republic of China
Shuang Liu, Min Liu, Hongchao Jiao, Xiaojuan Wang, Jingpeng Zhao & Hai Lin 1.
College of Life Sciences, Shandong Agricultural University, Tai’an, People’s Republic of China
Haifang Li, Rui Li, Yaxin Chang, Zhengang Wang, Yawen Sun, Mengying Li & Bin Li 1.
Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, the Third People’s Hospital of Chengdu, Chengdu, People’s Republic of China
Senlin Wang, Tongtong Zhang, Zhonghui Feng & Junbo Xu 1.
College of Chemistry and Materials Science, Shandong Agricultural University, Tai’an, People’s Republic of China
Yunlei Zhou
Authors
- Shuang Liu
- Haifang Li
- Rui Li
- Yaxin Chang
- Senlin Wang
- Zhengang Wang
- Yawen Sun
- Mengying Li
- Min Liu
- Yunlei Zhou
- Hongchao Jiao
- Xiaojuan Wang
- Jingpeng Zhao
- Bin Li
- Tongtong Zhang
- Zhonghui Feng
- Junbo Xu
- Hai Lin
Contributions
Conceptualization: H.F.L., H.L., Z.H.F., J.B.X., and S.L.; data curation: S.L. and H.F.L.; formal analysis: S.L., H.F.L., R.L, Y.X.C., S.L.W., Z.G.W., Y.W.S., and M.Y.L.; funding acquisition: H.L., H.F.L., J.B.X., and Z.H.F.; investigation and resources: M.L., Y.L.Z., X.J.W., H.C.J., J.P.Z., B.L., and T.T.Z.; supervision: H.F.L., H.L., J.B.X., and Z.H.F.; writing – original draft: S.L., and H.F.L.; writing – review & editing, all authors.
Corresponding authors
Correspondence to Haifang Li, Zhonghui Feng, Junbo Xu or Hai Lin.
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Liu, S., Li, H., Li, R. et al. Prevotella copri promotes white adipose browning and ameliorates adiposity. Nat Commun (2025). https://doi.org/10.1038/s41467-025-67327-x
Received: 18 November 2024
Accepted: 27 November 2025
Published: 13 December 2025
DOI: https://doi.org/10.1038/s41467-025-67327-x