Data availability

The data that support the findings of this study are openly available in GEO with the accession number GSE305056 (https://identifiers.org/geo/GSE305056) and ProteomeXchange via PRIDE14 with identifier PXD067973 (https://identifiers.org/pride.project:PXD067973).

Code availability

No specific code was developed in this work. The parameters of bioinformatics tools and all software used for data processing are described in the Methods section. If no detailed parameters are mentioned, the default parameters were used.

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Acknowledgements

This work is supported by start up research grant in Hunan Normal University (No.0531120 and 0531320). We would like to thank Shanghai Bioprofile Technology Company for technical support with RNA-seq and LC-MS/MS.

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Author notes

These authors contributed equally: Qiuyan Zhu, Shuo Wang.

Authors and Affiliations

The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Science, Hunan Normal University, Changsha, Hunan, 410081, China

Qiuyan Zhu, Shuo Wang, Hao Zhou, Jianbo Yang, Yangya Liang, Xi Chen, Jianlin Zhou, Dandan Wu & Xing Zhang 1.

College of Clinical Laboratory, Changsha Medical University, Changsha, Hunan, 410219, China

Hao Zhou 1.

Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Science, Hunan Normal University, Changsha, Hunan, 410081, China

Xing Zhang

Authors

1. Qiuyan Zhu
2. Shuo Wang
3. Hao Zhou
4. Jianbo Yang
5. Yangya Liang
6. Xi Chen
7. Jianlin Zhou
8. Dandan Wu
9. Xing Zhang

Contributions

Q.Z. and S.W. Investigation, Formal analysis, Writing- Original draft preparation, Writing- Reviewing and Editing; H.Z., J.Y., Y.L. and X.C., Resources, Writing- Original draft preparation, Writing- Reviewing and Editing; J.Z., and D.W. Conceptualization, Writing- Original draft preparation, Writing- Reviewing and Editing; X.Z. Conceptualization, Funding acquisition, Writing- Original draft preparation, Writing- Reviewing and Editing.

Corresponding authors

Correspondence to Dandan Wu or Xing Zhang.

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The authors declare no competing interests.

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Zhu, Q., Wang, S., Zhou, H. et al. Temporal transcriptomic and proteomic characterization of adipose tissue from cold-exposed mice. Sci Data (2026). https://doi.org/10.1038/s41597-026-06709-2

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Received: 11 September 2025

Accepted: 23 January 2026

Published: 02 February 2026

DOI: https://doi.org/10.1038/s41597-026-06709-2