🧬 Genomics

DNA Sequencing, Genome Editing, CRISPR, Genetic Variation

Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology
nature.com·2d
🧮Computational Biology
Study reveals hidden regulatory roles of 'junk' DNA
phys.org·2d
📊Bioinformatics
On The Shoulders Of Substrates—how one phenomenon lays the foundation for the next
lesswrong.com·10h
🧮Computational Biology
E2F activity determines mitosis versus whole-genome duplication in G2-arrested cells
nature.com·1h
🧩DNA assembly
CompasSeq: epitranscriptome-wide percentage assessment of metabolite-capped RNA at the transcript resolution
nature.com·1d
🧩DNA assembly
A whole-organism landscape of X-inactivation in humans
elifesciences.org·4d
🧮Computational Biology
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing
nature.com·1d
🧮Computational Biology
Cancer DNA is detectable in blood years before diagnosis
sciencenews.org·2d·
Discuss: Hacker News
📊Bioinformatics
Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases
nature.com·2d
📊Bioinformatics
Where Are All the AI Drugs?
wired.com·3d·
Discuss: Hacker News
🧮Computational Biology
Single nucleosome imaging reveals principles of transient multiscale chromatin reorganization triggered by histone ADP-ribosylation at DNA lesions
nature.com·2d
🧩DNA assembly
Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids
nature.com·2d
📊Bioinformatics
Identification of functional non-coding variants associated with orofacial cleft
nature.com·4d
🧮Computational Biology
New pocket-size model of ALS 'breathes and flows like human tissue'
livescience.com·1d
🧮Computational Biology
"The Bitter Lesson" is wrong. Well sort of
assaf-pinhasi.medium.com·14h·
Discuss: Hacker News
🧮Computational Biology
Refined DNA repair manipulation enables a universal knock-in strategy in mouse embryos
nature.com·5d
🧩DNA assembly
Gene editing offers transformative solution to saving endangered species
phys.org·3d
📊Bioinformatics
The old Caveman Chemistry website
cavemanchemistry.com·17h·
Discuss: Hacker News
⚗️Food Chemistry
De novo designed protein guiding targeted protein degradation
nature.com·3d
🧮Computational Biology
Comprehensive <i>RAD51C</i> ovarian cancer variant analysis uncouples homologous recombination and replicative functions
nature.com·4d
🧩DNA assembly