Cell Chemical Biology · Scour

IAP-based biodegraders can convert necroptosis to apoptosis and eliminate cancer driving protein complexes

Sorting out extracellular proteins: SORTACs harness sortilin for targeted protein degradation

A nature-inspired nanoplatform for multi-protein targeted degradation via the autophagy-lysosome pathway

Reshaping the progranulin/sortilin interaction for targeted degradation of extracellular proteins

Distinct autophagy impairment mechanisms of huntingtin aggregates with different polyQ lengths

Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression

Membrane lipids regulate the STING pathway and type I interferon responses

Receptor-ubiquitination-targeting antibody-drug conjugates for enhanced endocytosis and lysosomal delivery

Directed evolution of APOX for proximity labeling using phenols with high redox potentials

Degrading TBK1 to disarm VHL-deficient renal cancer

Assessing the suitability of deubiquitylases as substrates for targeted protein degradation

Lysosome-targeting chimeras enable targeted protein degradation

Mechanosensation promotes broad-spectrum antiviral defense through membrane remodeling

Divide and conquer: Dissecting the host machinery underlying influenza virus transcription and replication

The membrane strikes back: A mechanical force awakens antiviral defense

De novo design of Ras isoform selective binders

Cytoplasmic tail diversity determines the effector bias of the adhesion GPCR ADGRL2

Discovery of MARK2 as a physiological kinase for PER2 in the mammalian clock

Advances in degradomics technologies to assess proteolytic cleavage events

Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells

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