Cell Chemical Biology · Scour

Oxidizing to optimize stemness and antitumor immunity

Intracellular cyclization-coupled peptide library screening yields potent transcription factor antagonists

A small molecule PTER-selective inhibitor reduces food intake and body weight

Influenza A virus polymerase co-opts distinct sets of host proteins for RNA transcription or replication

De novo protein assembly enables drug-controlled cellular functions

Deciphering phosphorylation TACtics: Advances in phosphorylation targeting strategies and bifunctional modalities

Decoding E1-E2 specificity: How UBA6 prioritizes BIRC6 for ubiquitin conjugation

Structural basis for NONO-specific modification by the α-chloroacetamide compound (R)-SKBG-1

Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation

The HEAT repeat protein MROH7 regulates the inflammatory macrophage response via LBP acetylation

Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS

Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO

Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis

Exporter Mdr1 as an importer is an achilles’ heel for combating drug-resistant Candida

What’s the good word? Lactobacilli produce peptidoglycan fragments with the right structure to induce tolerance during colitis

Discovery of bioactive peptidoglycan fragments from Lactobacillaceae that confer intestinal protection in hosts

Beyond a degrader: VHL reprograms hypoxic metabolism

Targeting the endocannabinoid-eicosanoid axis to treat pain: Promise and pitfalls

Identification of aryl hydrocarbon receptor as a functional target that enhances astrocytic ApoE secretion

Targeted discovery of aromatic glycosides with dual detoxification effects via a highly customized molecular networking platform

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