Cell Chemical Biology · Scour

Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation

An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment

Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor

A widespread and ancient bacterial machinery assembles cytochrome OmcS nanowires essential for extracellular electron transfer

An engineered cereblon optimized for high-throughput screening and molecular glue discovery

Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders

Dynamic sampling of a surveillance state enables DNA proofreading by Cas9

Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen

SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy

A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells

The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells

Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases

A PROTAC degrader suppresses oncogenic functions of PTK6, inducing apoptosis of breast cancer cells

Next steps for targeted protein degradation

Log in to enable infinite scrolling